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Product Description

Lab-in-a-Tip(TM) high-capacity no-filter micro-SPE cartridge

  • Simple, fast "aspiration"-type sample prep with minimal loss
  • Patented no-filter design allows for reduced contamination, no back pressure (loose chromatographic media held between two twists)
  • Binding capacity of 100-500 µg, other custom binding capacities available on request
  • Fits on standard 10-200 µL pipettes, as well as automated liquid handling platforms

Glygen is proud to introduce the NEW patented TwisTip: a new "twist" in SPE sample preparation in a tip.

The patented TwisTip contains dispersive chromatographic media with no filter - eliminating contamination risks and dramatically improving sample recovery. Sample is simply aspirated into and expelled from the TwisTip for binding, washing, and purification (using any standard pipettor or automated liquid handling platform). Target molecules bind within the chromatographic media chamber as impurities are washed out; the target molecules are then released from the media for purified sample.

In TwisTip, nothing gets in between your samples and the chromatographic media. The loose chromatographic media in the TwisTip is trapped between the two twists at the lower end of the tip. This patented twisting design makes a spiral capillary that holds the chromatographic media in place in the pipette tip without any filters.

In addition to standard pipettors and automated liquid handling platforms, TwisTip can also be used with any syringe , vacuum or centrifugation system. Each box comes with centrifuge adaptors for micro-centrifuge.

At present, the TwisTip is available with the following chromatographic media: Silica, C18, Carbon, Carbon+C18, DOWEX(TM) Weak/Strong Anion/Cation exchangers (which can be used in any pH 0-14), and TiO2. Other media available on request.

Glygen’s other successful products are NuTip(TM) and TopTip(TM), and their applications have resulted in more than 300 publications worldwide.



TwisTips are available in boxes of 96 tips

TwisTip Chromatographic Media Volume: 10µL

Biinding capacity: ~100-500µg (depending upon target molecule)

Pipette Tip Size: 10-200µL



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