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Product Description

Micro-spin column (no filter) for low concentration and low volume small molecule samples
C18 • C08 • C04 • Carbon • HILIC • Gel Filtration

  • Significantly reduce time and expense of SPE (e.g., can top-load samples and centrifuge)
  • Dispersive media with no filter, glue, or polymer: improves binding, sample recovery, and reproducibility
  • Accommodates wide spectrum of volumes and allows precise control over binding and elution rates
  • Ideal for isolating low-abundance small molecules

Small Molecule Enrichment TopTip is based on Glygen’s proprietary micro-spin column technology, enabling high-fidelity separation of low-concentration/volume samples.

The fine slit at the bottom of the TopTip (slit width: 1-2 µm) permits liquid to pass through, but retains chromatographic material in the tip. This unique design eliminates the need for a filter – reducing dead volume, loss of sample and contamination risk.

Elution pressure can be generated using any centrifuge (adaptor included), or manually with a syringe.

Learn more about TopTip technology.

TopTip technology has powered research resulting in many publications: Explore literature featuring TopTip.


How TopTip works

how-to-toptip.png


Media selection
Protein/Peptide Desalting TopTips are available with a wide selection of chomatographic media.

Media Use for
C18 Hydrophobic (Highest)
C8 Hydrophobic (High)
C4 Hydrophobic
Carbon (Graphite) Both hydrophobic and hydrophilic
HILIC Hydrophilic
G-10, G-25, G-50, 
G-100, P-2, P-4, P-6,  Size-based gel filtration

Specifications
Sold in packs of 96, except for TT3, which are sold in packs of 20.

  Volume (ul) Binding capacity Media amount
TT1 1-10 400 µg 4 mg
TT2 10-200 1000 µg 10 mg
TT3 100-1000 5000 µg 50 mg

 

Ordering information

Part no. Price ($) Specs  
TT1C18 181 Size: TopTip (1-10 µL) Media: C18
TT1C08 181 Size: TopTip (1-10 µL) Media: C8
TT1C04 181 Size: TopTip (1-10 µL) Media: C4
TT1CAR 243 Size: TopTip (1-10 µL) Media: Carbon (Graphite)
TT1HIL 206 Size: TopTip (1-10 µL) Media: HILIC
TT1G10 118 Size: TopTip (1-10 µL) Media: G-10
TT1G25 118 Size: TopTip (1-10 µL) Media: G-25
TT1G50 118 Size: TopTip (1-10 µL) Media: G-50
TT1G100 118 Size: TopTip (1-10 µL) Media: G-100
TT1P2 118 Size: TopTip (1-10 µL) Media: P-2
TT1P4 118 Size: TopTip (1-10 µL) Media: P-4
TT1P6 118 Size: TopTip (1-10 µL) Media: P-6
TT2C18 218 Size: TopTip (10-200 µL) Media: C18
TT2C08 218 Size: TopTip (10-200 µL) Media: C8
TT2C04 218 Size: TopTip (10-200 µL) Media: C4
TT2CAR 331 Size: TopTip (10-200 µL) Media: Carbon (Graphite)
TT2HIL 281 Size: TopTip (10-200 µL) Media: HILIC
TT2G10 118 Size: TopTip (10-200 µL) Media: G-10
TT2G25 118 Size: TopTip (10-200 µL) Media: G-25
TT2G50 118 Size: TopTip (10-200 µL) Media: G-50
TT2G100 118 Size: TopTip (10-200 µL) Media: G-100
TT2P2 118 Size: TopTip (10-200 µL) Media: P-2
TT2P4 118 Size: TopTip (10-200 µL) Media: P-4
TT2P6 118 Size: TopTip (10-200 µL) Media: P-6
TT3C18 118 Size: TopTip (100-1000 µL) Media: C18
TT3C08 118 Size: TopTip (100-1000 µL) Media: C8
TT3C04 118 Size: TopTip (100-1000 µL) Media: C4
TT3CAR 206 Size: TopTip (100-1000 µL) Media: Carbon (Graphite)
TT3HIL 156 Size: TopTip (100-1000 µL) Media: HILIC
TT3G10 118 Size: TopTip (100-1000 µL) Media: G-10
TT3G25 118 Size: TopTip (100-1000 µL) Media: G-25
TT3G50 118 Size: TopTip (100-1000 µL) Media: G-50
TT3G100 118 Size: TopTip (100-1000 µL) Media: G-100
TT3P2 118 Size: TopTip (100-1000 µL) Media: P-2
TT3P4 118 Size: TopTip (100-1000 µL) Media: P-4
TT3P6 118 Size: TopTip (100-1000 µL) Media: P-6



Small Molecule Enrichment TopTip

Price:
$95.00


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